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KMID : 0648320060120040023
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Journal of The Korean Society of Hypertension
2006 Volume.12 No. 4 p.23 ~ p.30
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Comparison of Adriamycin-Induced Cardiomyopathy in Normotensive Rats and Spontaneously Hypertensive Rats
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Uhm Jae-Sun
Youn Ho-Joong
Choi Yun-Seok
Lee Dong-Hyeon
Yoon Hee-Jung
Park Chul-Soo
Oh Yong-Seog
Chung Wook-Sung
Kim Jae-Hyung
Choi Kyu-Bo
Hong Soon-Jo
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Abstract
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Background: Adriamycin has the limitation of its usage because of severe cardiotoxicity. Hypertension has been known as the important risk factor of adriamycin-induced cardiomyopathy. The influence of hypertension on adriamycininduced cardiomyopathy has not elucidated. We intended to elucidate the effects of hypertension on adriamycin-induced cardiomyopathy.
Methods: Normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were randomly divided into adriamycin-treated groups or saline-treated groups. Adriamycin with the dosage of 2.5 mg/kg was administrated intraperitoneally 2 times per week for 3 weeks for adriamycin-treated groups. Transthoracic echocardiography with a 15-MHz linear array transducer was performed at baseline and at sixth week to measure fractional shortening of the left ventricle. Histologic analyses with picrosirius red stain were performed for quantifying perivascular and interstitial fibrosis.
Results: (1) In adriamycin-treated WKY group, the left ventricular systolic function was decreased significantly (p<0.05), and fibrosis of perivascular and interstitial area was increased significantly (p<0.05, p<0.05), compared with saline-treated WKY group. (2) In saline-treated SHR group, fibrosis of perivascular and interstitial area was increased significantly (p<0.05, p<0.05), compared with saline-treated WKY group. (3) In adriamycin-treated SHR group, the left ventricular systolic function was decreased significantly (p<0.05), the fibrosis of perivascular area was increased significantly (p<0.05), compared with saline-treated SHR group. (4) In adriamycin-treated SHR group, the fibrosis of perivascular and interstitial area was increased significantly (p<0.05, p<0.05), compared with adriamycin-treated WKY.
Conclusion: These results suggest the perivascular fibrosis induced by hypertension may have influence on adriamycin-induced cardiomyopathy.
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KEYWORD
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adriamycin, hypertension, cardiomyopathy, fibrosis
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